NEW QUINOLINE DERIVATIVES WITH POTENTIAL BIOLOGICAL ACTIVITY
نویسندگان
چکیده
منابع مشابه
Synthesis and reactions of some new quinoline thiosemicarbazide derivatives of potential biological activity
Quinoline-2-carbohydrazide (3) was reacted with aryl or alkyl isothiocyanates to give the corresponding quinoline thiosemicarbazides (4a-e). Cyclization of the substituted thiosemicarbazides with sodium hydroxide led to the formation of 5-(quinolin-2-yl)2H-1, 2, 4-triazole-3(4H)-thiones (5a-e). Desulfurization of thiosemicarbazides by mercuric oxide gave 5-(quinolin-2-yl)-1, 3, 4-oxadiazol2-ami...
متن کاملSynthesis of Some New Heterocyclic Compounds with Potential Biological Activity
A series of new 2-arylimino-3-aryl-5-[5?-(3,4-dichlorophenyl)-2?-furylidene]-4-thiazolidinones (3a-l) have been synthesised by the condensation of 5-(3,4-dichlorophenyl)-2-furaldehyde 1 with 2-arylimino-3-aryl-5H-4-thiazolidinones 2 in glacial acetic acid. The physical and spectral data of the synthesised compounds are determined. The synthesised compounds have been screened for their in vitro ...
متن کاملCurcumin Derivatives with Potential Biological Activity
Curcumin 9a, extracted from Curcuma Longa, is a strong antioxidant that offers a good protection against injuries caused by free radicals [1-3], more active than vitamin E. Curcumin possesses also a good antibacterial and antiseptic, strong antiinflammatory, intestinal disinfectant properties, being also a good stimulant for the blood circulation. [4, 5]. The paper presents the synthesis of a s...
متن کاملSynthesis and biological activities of new substituted thiazoline-quinoline derivatives.
5-Acyl-8-hydroxyquinoline-2-(3'-substituted-4'-aryl-2,3-dihydrothiazol-2'-ylidene)hydrazones, 5a-e to 10a-c, were prepared by the reaction of appropriate 5-acyl-8-hydroxyquinoline-4-substituted thiosemicarbazones 3a-e and phenacyl bromides 4a-e. Structures of the new compounds were verified on the basis of spectral and elemental analyses. Twenty-eight new compounds were tested for their possibl...
متن کامل[New coumarin derivatives with expected biological activity].
A number of novel 3-bromo-4-methyl-7-methoxy-8-amino substituted coumarins and 2-substituted 7-bromo-6-methyl-8H-pyrano-benzimidazoles, benzoxazoles and/or benzoxazine-8-ones were synthesized for the purpose of pharmacological evaluation. Some representative compounds showed antitumor activity in vitro on Ehrlich ascites carcinoma in the preliminary testing.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Applied and Fundamental Research (Международный журнал прикладных и фундаментальных исследований)
سال: 2019
ISSN: 1996-3955
DOI: 10.17513/mjpfi.12894